Memantine can be taken with or without food. Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce.

Can you dissolve memantine in water?

If you have been given soluble tablets, dissolve the tablet in half a glass of water and drink it straightaway. Alternatively, soluble tablets can be swallowed whole with a drink of water.

Can memantine capsule be opened?

Memantine hydrochloride extended-release capsules can be taken intact or may be opened, sprinkled on applesauce, and thereby swallowed.

Can memantine ER be crushed?

You may take this medicine with or without food. Swallow the extended-release capsules whole. Do not break, crush, or chew them.

Which tablets Cannot be crushed?

1 Most of the no-crush medications are sustained-release, oral-dosage formulas. The majority of extended-release products should not be crushed or chewed, although there are some newer slow-release tablet formulations available that are scored and can be divided or halved (e.g., Toprol XL).

Can memantine be stopped suddenly?

Although memantine is widely used and generally considered safe, an abrupt cessation of memantine may result in discontinuation syndrome that can be distressing and result in decline of natural course. We report two patients who developed significant behavior disturbance after abrupt cessation of memantine.

Does memantine need to be tapered off?

PP: The dose of the cholinesterase inhibitors and/or memantine should be tapered prior to discontinuation by halving the dose (or by stepping down through available dose formulations) every four weeks to the lowest available dose, followed by discontinuation.

Should memantine be taken at night?

Take this medicine at bedtime unless your doctor tells you otherwise. You may take donepezil and memantine with or without food. Do not crush, chew, or break an extended-release capsule. Swallow it whole.

How long should you take memantine?

Memantine is available in either 10mg or 20mg tablets. Tablets should be swallowed with water, and can be taken with or without food. Usually people start with a low dose of 5mg once per day. The dose is then gradually increased over about four weeks to a maintenance dose of typically 20mg once per day.

How do I take memantine twice a day?

The recommended starting dose of NAMENDA is 5 mg (2.5 mL) once daily. The dose should be increased in 5 mg increments to 10 mg/day (2.5 mL twice daily), 15 mg/day (2.5 mL and 5 mL as separate doses), and 20 mg/day (5 mL twice daily). The minimum recommended interval between dose increases is one week.

What is the side effect of memantine?

SIDE EFFECTS: Body aches, dizziness, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Does memantine cause insomnia?

Memantine is used for the treatment of moderate or severe AD. It is well known that memantine acts as a blocker on N-methyl-D-aspartate (NMDA) receptors. It produces wake promotion and insomnia in AD patients [10].

What is memantine HCL 5mg used for?

Memantine is used to treat the symptoms of Alzheimer’s disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain.

Can you split a pill that is not scored?

Many pills that can be safely split have a “score”, a line down the middle of the pill, that allows for easier splitting. However, be aware that not all tablets that are scored are safe to split in half, so ask your pharmacist first. On the other hand, some tablets that are not scored can be safely cut in half.

What drugs are not split list?

Drugs that should usually not be split include capsules, chemotherapy drugs, birth control pills, seizure-related medications, and any pill that has a coating or other controlled- or extended-release feature. Be sure to check with your doctor prior to splitting any medication.

What happens if you chew a pill that is supposed to be swallowed?

Some medicines are specially prepared to deliver the medicine to your body slowly, over time. If these pills are crushed or chewed, or the capsules are opened before swallowing, the medicine may go into the body too fast, which can cause harm.

Who should not take memantine?

Memantine hydrochloride is not recommended for children and adolescents under the age of 18 years. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

How do I wean myself off memantine?

What is the recommended discontinuation process? Taper the drug by decreasing the dose by half for two weeks and then stop. Assess for any reappearance of behavioral or psychological symptoms. If they recur, restart the medication at the effective dose.

Does memantine improve memory?

Memantine is a prescription drug used to treat moderate to severe confusion (dementia) related to Alzheimer’s disease. It does not cure Alzheimer’s disease, but it may improve memory, awareness, and the ability to perform daily functions.

Can you take memantine long term?

Take as directed. Memantine oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed. If you stop taking the drug or don’t take it at all: Your dementia symptoms may not be relieved, and they may get worse.

Can memantine cause loss of appetite?

In a therapeutic trial in five obese women, Hermanussen et al. found that memantine could significantly suppress the appetite and binge-eating disorder and finally decrease the body weight within a few days (5).

Is memantine any good?

Memantine has an average rating of 4.6 out of 10 from a total of 38 ratings for the treatment of Alzheimer’s Disease. 32% of reviewers reported a positive effect, while 50% reported a negative effect.

Does memantine help with aggression?

Findings from a recent study presented at the annual meeting of the American Association of Geriatric Psychiatry suggest that memantine (Namenda) therapy may significantly reduce agitation or aggression as well as improve appetite in patients with moderate-to-severe AD who are already receiving stable doses of Nov 23, 2005.

What time of day is best to take memantine?

Memantine is usually taken once a day, in the morning, at the same time each day. However, you and your prescriber may decide that it is better for you to take the medicine at another time.

About the Author

Tommy E. Junkins

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